Nature has granted Madhya Pradesh with rich and diverse forest resources. The tribal residing in Alirajpur of western Madhya Pradesh are uneducated, socio-economically backward and still depend on medicinal plants for the treatment of various diseases. The objective of the present study was to find out ethno medicinal claims of some unique rare and threatened medicinal plants utilized by tribal in this district. Data obtained by periodical and seasonal field trips, collection of information from tribal medicine men (Badwa), patients and elderly person in and around study area. Present investigation revealed that tribal are regularly using 52 species of plants belonging to 36 families to cure various diseases. The study also revealed new ethno medicinal uses of plants that are not available in the earlier literature. Many of the medicinal plant species are in list of endangered taxa. Therefore protection and its strategies conservation techniques of these plant species will help in maintaining ecological balance so that this heritage can be used smartly through careful management for future generation.