Transition Metal (II) Complexes With (E) – N – Phenyl-2-[Phenyl (Pyridine- 2-Yl) Methylene] Hydrazinecarb-Oxamide And Its Superoxide Dismutase (SOD) Activity

Abstract

A series of metal (II) complexes of the type [ M(L)2 ] (ClO4)2 where M = CO(II), Mn(II), Cu(II), Ni(II), Cd(II), Zn(II), L= (E) – N – Phenyl – 2 – [phenyl (pyridine-2-yl) methylene]hydazinecarboxamide, have been synthesized and characterized by elemental analyses, FAB (Fast atomic bombardment), magnetic measurments, electronic absorption, conductivity measurments, cyclic voltammetry(CV) and Electron Paramagnetic Resonance (EPR) spectroscopy. The epr spectra of these complexes in frozen solutions of DMSO showed a signal at g ca.2. The trend in g-value (g||>g >2.00) suggest that the unpaired electron on copper (II) has dx2-y2 character. Biological activities in terms of superoxide dismutase (SOD) and antimicrobial properties of Metal(II) complexes have also been measured. The superoxide dismutuse activity reveals that these complexes catalyze the fast dispropor-tionation of superoxide in DMSO solution.

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